NECTIN1

Across TCGA cell cohorts, NECTIN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,156 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NECTIN1-associated GO terms across cancer lineages are Regulation of mRNA processing, Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, and Cerebral cortex radial glia-guided migration. Each is linked with NECTIN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both NECTIN1-to-partner and partner-to-NECTIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA processing grouped by NECTIN1-low versus NECTIN1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN1→partner) and Y-score (partner→NECTIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of mRNA processing →	+0.072	+1.517	<.001	<.001	3	10
BONE	Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway →	+0.214	+1.243	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cerebral cortex radial glia-guided migration →	+0.106	+1.340	.004	.004	3	9
UPPER_AERODIGESTIVE_TRACT	Telencephalon glial cell migration →	+0.106	+1.340	.004	.004	3	9
SOFT_TISSUE	Negative regulation of mRNA catabolic process →	+0.063	+1.348	<.001	<.001	3	9
SOFT_TISSUE	Regulation of nucleotide-excision repair →	+0.088	+1.320	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,156 associations by consensus.

Regulation of mRNA processing by NECTIN1 expression — SOFT_TISSUE

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