NECTIN1-AS1

Across TCGA pan-cancer cohorts, NECTIN1-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated NECTIN1-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NECTIN1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NECTIN1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and MESO show a favorable association.

ACC, LIHC, and LAML are the cancer types where NECTIN1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.575	0.887	.002	57	view →
LIHC	OS	Tertile	All	0.606	0.791	.002	39	view →
LAML	DFS	Tertile	All	0.744	0.329	.001	36	view →
MESO	DFS	Tertile	All	0.740	0.237	.018	30	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	27	view →
READ	DFS	Tertile	II,III,IV	1.000	0.751	.009	24	view →
UCS	OS	Tertile	All	0.852	0.491	.012	22	view →
SARC	DFS	Tertile	All	0.317	0.607	.017	18	view →
SKCM	OS	Tertile	III,IV	0.136	0.401	.009	15	view →
ESCA	DFS	Median	All	0.922	0.513	.013	13	view →
OV	DFS	Quartile	All	0.627	0.521	.024	10	view →
COAD	DFS	Tertile	IV	0.149	0.529	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

NECTIN1-AS1–ACC (OS)

Open the ACC breakdown →