NECAP2

Across TCGA pan-cancer cohorts, NECAP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NECAP2 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NECAP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NECAP2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where NECAP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.835	1.000	.033	24	view →
PDAC	DFS	Tertile	All	0.913	0.742	.016	10	view →
CCRCC	DFS	Median	II,III,IV	0.794	0.483	.015	6	view →
GBM	OS	Quartile	All	0.701	0.963	.008	5	view →
LSCC	DFS	Tertile	II,III,IV	0.564	0.899	.013	5	view →
LUAD	OS	Tertile	III,IV	0.247	0.657	.015	4	view →
HNSC	DFS	Tertile	II,III,IV	0.889	0.984	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NECAP2–COAD (DFS)

Open the COAD breakdown →