NECAB2

Across TCGA cell cohorts, NECAB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,667 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NECAB2-associated GO terms across cancer lineages are Regulation of G protein-coupled receptor internalization, Nucleic acid transport, and RNA transport. Each is linked with NECAB2 in more than 10 cancer types. Because this analysis shows association rather than direction, both NECAB2-to-partner and partner-to-NECAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of G protein-coupled receptor internalization grouped by NECAB2-low versus NECAB2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NECAB2→partner) and Y-score (partner→NECAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of G protein-coupled receptor internalization →	-0.168	-1.597	<.001	<.001	3	11
BREAST	Nucleic acid transport →	+0.085	+0.611	.002	.001	3	9
BREAST	RNA transport →	+0.085	+0.611	.002	.001	3	9
LUNG_SCLC	Immune response-regulating cell surface receptor signaling pathway →	-0.054	-1.896	<.001	<.001	3	8
OESOPHAGUS	Nucleic acid catabolic process →	+0.061	+1.607	.002	<.001	3	8
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.139	+1.322	.002	.003	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,667 associations by consensus.

Regulation of G protein-coupled receptor internalization by NECAB2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →