NECAB1

Across TCGA cell cohorts, NECAB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,297 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NECAB1-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Ligand-gated ion channel signaling pathway, and Ionotropic glutamate receptor signaling pathway. Each is linked with NECAB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both NECAB1-to-partner and partner-to-NECAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMDA selective glutamate receptor signaling pathway grouped by NECAB1-low versus NECAB1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NECAB1→partner) and Y-score (partner→NECAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	-0.261	-0.755	<.001	.007	3	8
BREAST	Ligand-gated ion channel signaling pathway →	-0.131	-0.802	<.001	.007	3	8
LIVER	Ionotropic glutamate receptor signaling pathway →	-0.135	-0.918	.001	<.001	3	8
PANCREAS	Gap junction-mediated intercellular transport →	-1.425	-0.446	<.001	.004	3	8
LUNG_NSCLC_LUAD	Sodium ion homeostasis →	-0.174	-0.420	.001	.002	2	8
KIDNEY	Regulation of membrane lipid distribution →	-0.062	-0.720	.007	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,297 associations by consensus.

NMDA selective glutamate receptor signaling pathway by NECAB1 expression — URINARY_TRACT

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