NDUFS8

Across TCGA pan-cancer cohorts, NDUFS8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NDUFS8 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDUFS8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NDUFS8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where NDUFS8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.539	0.297	<.001	50	view →
CCRCC	OS	Median	All	1.000	0.886	.002	25	view →
LUAD	OS	Quartile	III,IV	0.800	1.000	.031	5	view →
LSCC	OS	Median	II,III,IV	1.000	0.886	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NDUFS8–PDAC (DFS)

Open the PDAC breakdown →