Across TCGA patient cohorts, NDUFS3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFS3-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and Caspase-7-cleavedD198. Each is linked with NDUFS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFS3-to-partner and partner-to-NDUFS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFS3→partner) and Y-score (partner→NDUFS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.203	+3.321	.044	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.249	-3.308	.004	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.816	+2.827	.008	.035	3	1
UCEC	Caspase-8 →	-0.269	-3.169	.041	.019	3	1
UCEC	VHL →	-0.923	-3.000	.009	.036	2	1
UCEC	EGFR_pY1068 →	-0.283	-3.321	.031	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

NDUFS3 survival (RNA) · tumor vs normal (RNA) · all NDUFS3 data types