NDUFB8

Across TCGA pan-cancer cohorts, NDUFB8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NDUFB8 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDUFB8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDUFB8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, HNSC, and COAD are the cancer types where NDUFB8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.614	0.840	.002	24	view →
HNSC	DFS	Tertile	IV	0.851	0.514	.005	20	view →
COAD	DFS	Median	All	0.888	1.000	.023	18	view →
CCRCC	OS	Tertile	All	1.000	0.912	.019	12	view →
GBM	DFS	Median	All	0.842	0.654	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NDUFB8–PDAC (DFS)

Open the PDAC breakdown →