Across TCGA pan-cancer cohorts, NDUFB1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated NDUFB1 data layer compared with 7 for mass-spec protein.
The strongest signal is observed in uveal melanoma (UVM), where higher NDUFB1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDUFB1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and LUSC show a favorable association.
UVM, UCS, and ACC are the cancer types where NDUFB1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.