Across TCGA pan-cancer cohorts, NDUFAF8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NDUFAF8 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NDUFAF8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NDUFAF8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where NDUFAF8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.758	0.935	.012	48	view →
CCRCC	DFS	Quartile	All	0.592	0.914	.002	22	view →
LSCC	DFS	Tertile	All	0.610	1.000	.013	3	view →
PDAC	DFS	Median	IV	0.749	0.217	.024	3	view →
LUAD	DFS	Median	III,IV	0.722	0.285	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: NDUFAF8 tumor-vs-normal RNA expression · all NDUFAF8 data types