NDUFAF6

Across TCGA pan-cancer cohorts, NDUFAF6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NDUFAF6 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDUFAF6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDUFAF6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where NDUFAF6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.427	0.761	.001	28	view →
HNSC	DFS	Median	III,IV	0.868	0.710	.021	20	view →
UCEC	DFS	Median	All	0.852	0.954	.021	2	view →
PDAC	OS	Median	III,IV	0.866	0.720	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NDUFAF6–CCRCC (DFS)

Open the CCRCC breakdown →