NDUFAF6

Across TCGA pan-cancer cohorts, NDUFAF6 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NDUFAF6’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NDUFAF6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NDUFAF6 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC and HNSC are the cancer types where NDUFAF6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFAF6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.725	<.001	9	view →
HNSC	Male	II,III,IV	−0.510	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

NDUFAF6–CCRCC

Open the CCRCC breakdown →