NDUFAF6

Across TCGA patient cohorts, NDUFAF6 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFAF6-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and Acetyl-a-Tubulin-Lys40. Each is linked with NDUFAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFAF6-to-partner and partner-to-NDUFAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NDUFAF6-low versus NDUFAF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFAF6→partner) and Y-score (partner→NDUFAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.271	-3.000	.020	.036	3	1
UCEC	eIF4E →	+0.203	+3.700	.038	.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.626	+2.584	.008	.011	3	1
UCEC	MEK1 →	+0.466	+3.321	.006	.010	3	1
UCEC	Notch1 →	+0.221	+3.009	<.001	.019	3	1
UCEC	Annexin_VII →	-0.163	-2.584	.012	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1068 by NDUFAF6 expression — UCEC

Explore this box plot interactively →