NDUFAF5

Across TCGA patient cohorts, NDUFAF5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFAF5-associated genes across cancer lineages are MIG-6, eEF2, and EGFR_pY1068. Each is linked with NDUFAF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFAF5-to-partner and partner-to-NDUFAF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by NDUFAF5-low versus NDUFAF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFAF5→partner) and Y-score (partner→NDUFAF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.106	+2.179	.042	.034	3	2
UCEC	eEF2 →	+0.533	+3.321	.004	.010	3	1
UCEC	EGFR_pY1068 →	-0.351	-3.321	.007	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.175	-3.169	.007	.018	3	1
UCEC	GATA6 →	-0.177	-3.314	.028	.010	3	1
UCEC	INPP4B →	-0.477	-3.308	.004	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MIG-6 by NDUFAF5 expression — UCEC

Explore this box plot interactively →