Across TCGA pan-cancer cohorts, NDUFAF4P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of NDUFAF4P1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where NDUFAF4P1 RNA is repressed in tumor relative to normal tissue. In most cancer types NDUFAF4P1 is over-expressed in tumor, although a few such as THCA and PAAD show the opposite, repressed pattern.
THCA, PAAD, and CHOL are the cancer types where NDUFAF4P1 tumor–normal differential expression is most reproducible.