NDUFAF4

Across TCGA pan-cancer cohorts, NDUFAF4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NDUFAF4 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDUFAF4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NDUFAF4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

CCRCC, HNSC, and COAD are the cancer types where NDUFAF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.194	0.732	.021	25	view →
HNSC	OS	Median	All	0.449	1.000	.023	15	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.903	.043	12	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.845	.011	9	view →
UCEC	DFS	Tertile	II,III,IV	0.628	1.000	.024	6	view →
PDAC	DFS	Quartile	II,III,IV	0.557	0.299	.024	5	view →
GBM	OS	Tertile	All	0.352	0.558	.027	4	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NDUFAF4–CCRCC (OS)

Open the CCRCC breakdown →