NDUFAF3

Across TCGA pan-cancer cohorts, NDUFAF3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDUFAF3 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NDUFAF3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDUFAF3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

UCEC, LSCC, and GBM are the cancer types where NDUFAF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.429	1.000	.006	16	view →
LSCC	OS	Median	II,III,IV	1.000	0.883	.019	6	view →
GBM	OS	Tertile	All	0.285	0.532	.013	4	view →
PDAC	DFS	Quartile	III,IV	0.437	0.907	.021	4	view →
LUAD	DFS	Median	All	1.000	0.898	.021	2	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.846	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDUFAF3–UCEC (DFS)

Open the UCEC breakdown →