NDUFAF3

Across TCGA pan-cancer cohorts, NDUFAF3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NDUFAF3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NDUFAF3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NDUFAF3 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where NDUFAF3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFAF3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	−0.705	<.001	12	view →
HNSC	Male	II,III,IV	−0.420	<.001	12	view →
LSCC	Male	All	+0.181	<.001	4	view →
LUAD	All	All	+0.107	.004	4	view →
PDAC	Female	II,III,IV	−0.571	<.001	2	view →
COAD	All	All	+0.079	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NDUFAF3–CCRCC

Open the CCRCC breakdown →