NDUFAF2

Across TCGA pan-cancer cohorts, NDUFAF2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NDUFAF2 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher NDUFAF2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDUFAF2 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

GBM, CCRCC, and HNSC are the cancer types where NDUFAF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.707	0.337	<.001	24	view →
CCRCC	DFS	Quartile	II,III,IV	0.380	0.806	.002	24	view →
HNSC	DFS	Median	III,IV	0.485	0.745	.002	12	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	10	view →
UCEC	DFS	Tertile	III,IV	1.000	0.535	.049	4	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
LSCC	DFS	Quartile	II,III,IV	0.939	0.655	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NDUFAF2–GBM (OS)

Open the GBM breakdown →