NDUFA8

Across TCGA pan-cancer cohorts, NDUFA8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDUFA8 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDUFA8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDUFA8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where NDUFA8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.909	0.610	.009	24	view →
LUAD	DFS	Tertile	All	0.835	1.000	.012	12	view →
PDAC	OS	Quartile	II,III,IV	0.614	0.319	.020	10	view →
UCEC	OS	Median	All	0.969	0.856	.026	8	view →
HNSC	DFS	Quartile	II,III,IV	0.834	1.000	.003	5	view →
GBM	DFS	Quartile	All	0.767	0.522	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDUFA8–CCRCC (OS)

Open the CCRCC breakdown →