Across TCGA pan-cancer cohorts, NDUFA3P6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NDUFA3P6’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NDUFA3P6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NDUFA3P6 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
HNSC and BRCA are the cancer types where NDUFA3P6 tumor–normal differential expression is most reproducible.