NDUFA3

Across TCGA pan-cancer cohorts, NDUFA3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NDUFA3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDUFA3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NDUFA3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where NDUFA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.915	0.544	.003	34	view →
HNSC	DFS	Quartile	All	0.606	0.861	.005	31	view →
PDAC	OS	Quartile	III,IV	0.968	0.262	.006	8	view →
LSCC	OS	Median	II,III,IV	1.000	0.905	.021	6	view →
LUAD	OS	Tertile	II,III,IV	0.774	0.398	.013	6	view →
UCEC	OS	Median	All	0.960	0.864	.037	2	view →
GBM	DFS	Quartile	All	0.856	0.635	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NDUFA3–CCRCC (DFS)

Open the CCRCC breakdown →