NDUFA3

Across TCGA patient cohorts, NDUFA3 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. CESC shows the largest number of these associations.

The most reproducible NDUFA3-associated genes across cancer lineages are RBMY2EP, NPBWR2, and HNRNPCL4. Each is linked with NDUFA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFA3-to-partner and partner-to-NDUFA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY2EP grouped by NDUFA3-low versus NDUFA3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFA3→partner) and Y-score (partner→NDUFA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RBMY2EP →	+0.715	+5.303	<.001	.006	3	1
CESC	NPBWR2 →	+0.029	+5.010	.001	.009	3	1
CESC	HNRNPCL4 →	+0.042	+5.103	.001	.008	3	1
CESC	DEFB123 →	+0.088	+5.010	.002	.009	3	1
CESC	S100A7L2 →	+0.108	+5.010	<.001	.009	3	1
CESC	RNA5SP432 →	+0.349	+5.539	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

RBMY2EP by NDUFA3 expression — HNSC

Explore this box plot interactively →