NDUFA2

Across TCGA pan-cancer cohorts, NDUFA2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NDUFA2 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NDUFA2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NDUFA2 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

LUAD, HNSC, and GBM are the cancer types where NDUFA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.330	0.869	.006	17	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	13	view →
GBM	DFS	Median	All	0.866	0.641	.003	10	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.214	.006	6	view →
CCRCC	OS	Median	All	0.961	0.820	.001	5	view →
PDAC	OS	Tertile	All	0.683	0.482	.024	3	view →
UCEC	OS	Median	All	0.965	0.862	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NDUFA2–LUAD (OS)

Open the LUAD breakdown →