NDUFA11

Across TCGA patient cohorts, NDUFA11 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFA11-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with NDUFA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFA11-to-partner and partner-to-NDUFA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NDUFA11-low versus NDUFA11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFA11→partner) and Y-score (partner→NDUFA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.373	-3.584	.002	.002	3	1
UCEC	eIF4E →	+0.286	+3.013	.004	.018	3	1
UCEC	eIF4G →	+0.331	+3.169	.027	.019	3	1
UCEC	A-Raf_pS299 →	-0.149	-2.999	.009	.035	3	1
UCEC	FoxM1 →	+0.264	+2.817	.035	.036	3	1
UCEC	ACC1 →	+0.620	+3.183	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

EGFR_pY1068 by NDUFA11 expression — UCEC

Explore this box plot interactively →