NDRG3

Across TCGA pan-cancer cohorts, NDRG3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDRG3 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDRG3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDRG3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where NDRG3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.846	0.981	<.001	81	view →
HNSC	DFS	Tertile	IV	0.636	0.931	.028	4	view →
UCEC	OS	Median	III,IV	0.554	0.884	.045	4	view →
LSCC	DFS	Median	All	0.877	0.718	.031	3	view →
GBM	DFS	Quartile	All	0.808	0.607	.031	1	view →
LUAD	DFS	Quartile	All	0.998	0.809	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDRG3–CCRCC (DFS)

Open the CCRCC breakdown →