NDRG3

Across TCGA patient cohorts, NDRG3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDRG3-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and MEK1. Each is linked with NDRG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDRG3-to-partner and partner-to-NDRG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NDRG3-low versus NDRG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDRG3→partner) and Y-score (partner→NDRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.934	+2.720	<.001	.003	3	2
UCEC	4E-BP1 →	+0.270	+2.351	.015	.018	3	2
UCEC	MEK1 →	+0.321	+1.807	.033	.027	3	1
UCEC	PCNA →	+0.218	+2.321	.014	.006	3	1
UCEC	PDCD4 →	-0.575	-2.312	.003	.034	3	1
UCEC	Annexin-1 →	+0.483	+3.189	.026	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by NDRG3 expression — UCEC

Explore this box plot interactively →