NDRG2

Across TCGA pan-cancer cohorts, NDRG2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NDRG2 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDRG2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NDRG2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and UCEC are the cancer types where NDRG2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.853	0.671	<.001	72	view →
COAD	DFS	Median	II,III,IV	1.000	0.911	.012	66	view →
UCEC	OS	Median	III,IV	0.449	1.000	.010	16	view →
CCRCC	DFS	Quartile	III,IV	0.812	0.330	.004	16	view →
LSCC	DFS	Quartile	III,IV	0.843	0.191	.013	12	view →
HNSC	OS	Median	III,IV	1.000	0.449	.023	3	view →
LUAD	DFS	Tertile	All	0.782	0.497	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NDRG2–PDAC (DFS)

Open the PDAC breakdown →