NDRG2

Across TCGA patient cohorts, NDRG2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDRG2-associated genes across cancer lineages are Rad50, Tuberin_pT1462, and ASNS. Each is linked with NDRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDRG2-to-partner and partner-to-NDRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by NDRG2-low versus NDRG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDRG2→partner) and Y-score (partner→NDRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.244	-2.906	.017	.001	3	2
UCEC	Tuberin_pT1462 →	+0.235	+2.469	.016	.010	3	2
UCEC	ASNS →	+0.329	+3.169	.032	.019	3	2
UCEC	14-3-3_beta →	-0.088	-3.143	.039	.018	3	1
UCEC	eIF4E →	+0.184	+2.222	.040	.011	3	1
UCEC	eIF4G →	+0.289	+3.169	.028	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Rad50 by NDRG2 expression — UCEC

Explore this box plot interactively →