NDP

Across TCGA pan-cancer cohorts, NDP RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NDP’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NDP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NDP is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.

LUAD, UCEC, and COAD are the cancer types where NDP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.661	<.001	8	view →
UCEC	All	All	−2.766	<.001	6	view →
COAD	All	All	+0.412	.001	5	view →
LIHC	All	All	+0.029	.011	4	view →
LUSC	Male	All	+0.460	<.001	3	view →
PRAD	All	All	−1.438	<.001	2	view →
ESCA	All	All	+0.715	.018	2	view →
KIRP	All	All	−0.197	.011	2	view →
KICH	All	III,IV	−0.191	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NDP–LUAD

Open the LUAD breakdown →