NDFIP2

Across TCGA patient cohorts, NDFIP2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDFIP2-associated genes across cancer lineages are ATM, C-Raf, and Caspase-8. Each is linked with NDFIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDFIP2-to-partner and partner-to-NDFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NDFIP2-low versus NDFIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDFIP2→partner) and Y-score (partner→NDFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.615	-3.169	.013	.020	3	1
UCEC	C-Raf →	+0.182	+3.169	.020	.020	3	1
UCEC	Caspase-8 →	-0.283	-3.169	.040	.020	2	1
UCEC	EGFR_pY1068 →	-0.282	-3.169	.040	.020	1	1
UCEC	JNK2 →	+0.295	+3.169	.006	.020	1	1
UCEC	Annexin-1 →	+0.974	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ATM by NDFIP2 expression — UCEC

Explore this box plot interactively →