NDFIP1

Across TCGA patient cohorts, NDFIP1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDFIP1-associated genes across cancer lineages are FOXO3a, JNK_pT183_Y185, and Ku80. Each is linked with NDFIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDFIP1-to-partner and partner-to-NDFIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by NDFIP1-low versus NDFIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDFIP1→partner) and Y-score (partner→NDFIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.101	-2.571	.032	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-3.169	.011	.019	3	1
UCEC	Ku80 →	+0.247	+1.887	.025	.031	3	1
UCEC	Shc_pY317 →	-0.204	-3.321	.003	.010	3	1
UCEC	VHL →	-1.165	-3.584	<.001	.002	3	1
UCEC	Bim →	-0.272	-2.584	.026	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FOXO3a by NDFIP1 expression — UCEC

Explore this box plot interactively →