NDE1

Across TCGA pan-cancer cohorts, NDE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NDE1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDE1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDE1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where NDE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.755	.014	6	view →
PDAC	DFS	Median	All	0.252	0.447	.009	6	view →
UCEC	DFS	Median	II,III,IV	0.869	0.532	.035	4	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	4	view →
LUAD	DFS	Median	All	0.838	0.956	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NDE1–CCRCC (OS)

Open the CCRCC breakdown →