NDE1

Across TCGA patient cohorts, NDE1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDE1-associated genes across cancer lineages are eIF4E, GATA6, and MEK1. Each is linked with NDE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDE1-to-partner and partner-to-NDE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NDE1-low versus NDE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDE1→partner) and Y-score (partner→NDE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.250	+3.335	.005	.005	3	2
UCEC	GATA6 →	-0.161	-2.985	.017	.034	3	2
UCEC	MEK1 →	+0.510	+2.700	<.001	.006	3	2
COAD	Annexin-1 →	+0.543	+3.178	.003	.010	3	2
UCEC	Bax →	+0.279	+2.222	.006	.011	3	2
UCEC	EGFR_pY1068 →	-0.264	-2.584	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by NDE1 expression — UCEC

Explore this box plot interactively →