NDE1

Across TCGA cell cohorts, NDE1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible NDE1-associated genes across cancer lineages are ZNF804B, CCDC60, and C1orf146. Each is linked with NDE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDE1-to-partner and partner-to-NDE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF804B grouped by NDE1-low versus NDE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDE1→partner) and Y-score (partner→NDE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF804B →	+0.015	+5.415	.001	.004	3	1
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
OVARY	TAS2R41 →	+0.043	+4.228	<.001	.006	3	1
OVARY	ARMH2 →	+0.052	+4.228	<.001	.006	3	1
OVARY	NLRP2B →	+0.059	+4.392	<.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ZNF804B by NDE1 expression — LARGE_INTESTINE

Explore this box plot interactively →