NDC80

Across TCGA patient cohorts, NDC80 mutation is significantly associated with the RNA expression of many other genes, with 3,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDC80-associated genes across cancer lineages are FLACC1, HK2, and HPGDS. Each is linked with NDC80 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDC80-to-partner and partner-to-NDC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLACC1 grouped by NDC80-low versus NDC80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDC80→partner) and Y-score (partner→NDC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FLACC1 →	-0.404	-3.890	.003	<.001	3	2
UCEC	HK2 →	+0.550	+2.733	.007	.003	3	2
UCEC	HPGDS →	-0.401	-3.692	.001	.001	3	2
UCEC	SLC27A4 →	+0.504	+2.589	<.001	<.001	3	2
UCEC	FAXDC2 →	-0.493	-3.906	.008	<.001	3	2
UCEC	SH3RF3 →	-0.680	-2.393	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,264 associations by consensus.

FLACC1 by NDC80 expression — UCEC

Explore this box plot interactively →