NDC80

Across TCGA patient cohorts, NDC80 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDC80-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and PCNA. Each is linked with NDC80 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDC80-to-partner and partner-to-NDC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NDC80-low versus NDC80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDC80→partner) and Y-score (partner→NDC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.194	+2.820	.010	.001	3	2
UCEC	mTOR_pS2448 →	-0.185	-2.986	<.001	<.001	3	2
UCEC	PCNA →	+0.281	+2.321	<.001	.001	3	2
UCEC	PDCD4 →	-0.497	-2.459	.003	.018	3	2
UCEC	ATM →	-0.566	-1.584	<.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.237	-2.415	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by NDC80 expression — UCEC

Explore this box plot interactively →