NDC1

Across TCGA patient cohorts, NDC1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDC1-associated genes across cancer lineages are Heregulin, INPP4B, and JNK2. Each is linked with NDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDC1-to-partner and partner-to-NDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by NDC1-low versus NDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDC1→partner) and Y-score (partner→NDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.119	-2.308	.012	.033	3	1
UCEC	INPP4B →	-0.276	-2.584	.026	.010	3	1
UCEC	JNK2 →	+0.269	+2.594	<.001	.006	3	1
UCEC	Ku80 →	+0.245	+3.183	.006	.009	3	1
UCEC	MEK1 →	+0.482	+3.807	<.001	<.001	3	1
UCEC	MSH2 →	-0.258	-2.433	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Heregulin by NDC1 expression — UCEC

Explore this box plot interactively →