NDC1

Across TCGA cell cohorts, NDC1 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NDC1-associated genes across cancer lineages are DNASE1L3, MYL2, and IFNA6. Each is linked with NDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDC1-to-partner and partner-to-NDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNASE1L3 grouped by NDC1-low versus NDC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDC1→partner) and Y-score (partner→NDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNASE1L3 →	+2.107	+3.864	<.001	.003	3	2
BLOOD_Leukemia	MYL2 →	+0.513	+3.567	<.001	.003	3	1
BLOOD_Leukemia	IFNA6 →	+0.172	+3.475	<.001	.006	3	1
BLOOD_Leukemia	GTSF1L →	+0.962	+3.619	<.001	.007	3	1
BLOOD_Leukemia	IL19 →	+0.133	+3.656	.003	.006	3	1
BLOOD_Leukemia	TRIM48 →	+0.096	+3.684	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

DNASE1L3 by NDC1 expression — BLOOD_Leukemia

Explore this box plot interactively →