NCSTN

Across TCGA pan-cancer cohorts, NCSTN mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NCSTN’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NCSTN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NCSTN is over-expressed in tumor.

CCRCC, COAD, and HNSC are the cancer types where NCSTN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCSTN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.396	<.001	11	view →
COAD	Female	III,IV	+0.366	<.001	9	view →
HNSC	Male	IV	+0.301	<.001	8	view →
LUAD	Female	III,IV	+0.553	<.001	7	view →
LSCC	All	All	+0.218	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NCSTN–CCRCC

Open the CCRCC breakdown →