NCS1

Across TCGA pan-cancer cohorts, NCS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NCS1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NCS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NCS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where NCS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.898	.004	21	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	19	view →
CCRCC	DFS	Tertile	III,IV	0.316	0.732	.003	18	view →
GBM	DFS	Quartile	All	0.871	0.630	.018	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NCS1–HNSC (DFS)

Open the HNSC breakdown →