NCS1

Across TCGA patient cohorts, NCS1 mutation is significantly associated with the RNA expression of many other genes, with 1,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCS1-associated genes across cancer lineages are RN7SL237P, NTF6G, and SNORD115-21. Each is linked with NCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCS1-to-partner and partner-to-NCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL237P grouped by NCS1-low versus NCS1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCS1→partner) and Y-score (partner→NCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL237P →	+0.271	+5.418	<.001	.005	3	2
CESC	NTF6G →	+0.093	+6.342	<.001	.001	3	2
BLCA	SNORD115-21 →	+0.432	+7.640	<.001	.009	3	2
BRCA	OR51G1 →	+0.059	+7.731	<.001	.009	3	1
BRCA	CLPTM1LP1 →	+0.064	+7.731	<.001	.009	3	1
UCEC	LIN7C →	+0.686	+3.502	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,726 associations by consensus.

RN7SL237P by NCS1 expression — CESC

Explore this box plot interactively →