NCS1

Across TCGA patient cohorts, NCS1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCS1-associated genes across cancer lineages are Fibronectin, IGFBP2, and JNK2. Each is linked with NCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCS1-to-partner and partner-to-NCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by NCS1-low versus NCS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCS1→partner) and Y-score (partner→NCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.356	-3.160	.031	.019	3	1
UCEC	IGFBP2 →	-0.767	-2.321	.018	.035	3	1
UCEC	JNK2 →	+0.341	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.413	+3.472	<.001	.002	3	1
UCEC	MEK1 →	+0.467	+3.321	.011	.010	3	1
UCEC	p62 Lck ligand →	+0.527	+2.179	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Fibronectin by NCS1 expression — UCEC

Explore this box plot interactively →