Across TCGA pan-cancer cohorts, NCR3LG1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NCR3LG1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where NCR3LG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NCR3LG1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.
COAD, KICH, and KIRC are the cancer types where NCR3LG1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCR3LG1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.