NCR2

Across TCGA patient cohorts, NCR2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCR2-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, A-Raf_pS299, and JNK2. Each is linked with NCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCR2-to-partner and partner-to-NCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by NCR2-low versus NCR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCR2→partner) and Y-score (partner→NCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.558	+3.009	.014	.019	3	2
UCEC	A-Raf_pS299 →	-0.168	-2.000	.001	.032	3	1
UCEC	JNK2 →	+0.258	+2.000	.003	.032	3	1
UCEC	MEK1 →	+0.416	+2.000	.011	.030	3	1
UCEC	Myosin-IIa_pS1943 →	+0.295	+2.713	.001	.003	3	1
UCEC	Myosin-IIa →	+0.235	+1.881	.006	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Acetyl-a-Tubulin-Lys40 by NCR2 expression — UCEC

Explore this box plot interactively →