Across TCGA pan-cancer cohorts, NCOR2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NCOR2 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NCOR2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NCOR2 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where NCOR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.494	0.822	<.001	82	view →
CCRCC	OS	Quartile	III,IV	0.360	0.918	.002	50	view →
PDAC	OS	Quartile	All	0.272	0.480	.023	18	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →
GBM	OS	Tertile	All	0.714	1.000	<.001	5	view →
LSCC	DFS	Median	All	0.966	0.911	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: NCOR2 tumor-vs-normal RNA expression · all NCOR2 data types