Across TCGA pan-cancer cohorts, NCOR1P4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NCOR1P4’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where NCOR1P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NCOR1P4 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
LIHC and KIRC are the cancer types where NCOR1P4 tumor–normal differential expression is most reproducible.