Across TCGA pan-cancer cohorts, NCOA6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NCOA6 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NCOA6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NCOA6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and LUAD are the cancer types where NCOA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.866	0.623	.002	38	view →
GBM	OS	Median	All	0.482	0.265	.003	13	view →
LUAD	DFS	Quartile	All	0.982	0.855	.024	13	view →
UCEC	OS	Median	All	0.979	0.864	.023	12	view →
PDAC	OS	Median	II,III,IV	0.808	0.900	.028	3	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: NCOA6 tumor-vs-normal RNA expression · all NCOA6 data types