NCOA5

Across TCGA pan-cancer cohorts, NCOA5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NCOA5 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NCOA5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NCOA5 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

COAD, GBM, and PDAC are the cancer types where NCOA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.914	.016	54	view →
GBM	OS	Tertile	All	0.543	0.285	.005	25	view →
PDAC	DFS	Median	III,IV	0.899	0.532	.005	20	view →
LUAD	OS	Median	All	1.000	0.642	.002	11	view →
HNSC	OS	Quartile	All	0.270	1.000	.040	5	view →
CCRCC	OS	Tertile	All	0.912	1.000	.023	4	view →
LSCC	OS	Median	II,III,IV	0.866	0.686	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NCOA5–COAD (DFS)

Open the COAD breakdown →