NCOA4

Across TCGA patient cohorts, NCOA4 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCOA4-associated genes across cancer lineages are C-Raf, ERK2, and P-Cadherin. Each is linked with NCOA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NCOA4-to-partner and partner-to-NCOA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by NCOA4-low versus NCOA4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA4→partner) and Y-score (partner→NCOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.219	+2.815	.006	.036	3	3
UCEC	ERK2 →	+0.185	+2.392	.006	<.001	3	2
UCEC	P-Cadherin →	-0.117	-2.321	.021	.033	3	2
UCEC	PCNA →	+0.279	+3.087	<.001	<.001	3	2
UCEC	RAD51 →	+0.143	+2.584	.003	.010	3	2
UCEC	ATM →	-0.613	-2.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C-Raf by NCOA4 expression — COAD

Explore this box plot interactively →